Phone:   (812)-856-1859
Fax:       (812)-856-4764
E-mail:   hatang (at) indiana.edu

Lab: Computational Omics Lab (COL)

Go to Bioinformatics programs at IU Bloomington

Mailing address:

Informatics Building
901 E. 10th St.
Bloomington, IN 47408-3912

Educaltional Background:

Research Interests:

Algorithmic and statistical problems in Bioinformatics, particularly in

•     repeats and segmental duplication in eukaryotic genomes
•     fragment assembly in DNA sequencing
•     mass spectrometry data analysis for proteomics, glycomics and glycoproteomics
•     gene regulatory analysis
  

Teaching:

Awards

1. NSF Early Career Development (CAREER) Award, 2007.

Books and Book Chapters

1. S. Kim, H. Tang and E. Mardis, ed. Genome sequencing technology and algorithms, Artech House Publishers (2007). Amazon
2. H. Tang and S. Kim, Bioinformatics: Mining the massive data from high throughput genomics experiments, pp1-24, in Analysis of Biological Data: A Soft Computing Approach, edited by Sanghamitra Bandyopadhyay, Ujjwal Maulik and Jason T. L. Wang, World Scientific Press (2007).
3. Y. Ye and H. Tang, Dynamic programming algorithms for sequence and structure comparison, pp9-28, in Bioinformatics Algorithms: Techniques and Applications , edited by Ion Mandoiu and Alexander Zelikovsky , Wiley Press (2008).

Recent Publications:

1. Q. Sheng, Y. Mechref, Y. Li, M. V. Novotny, H. Tang (2008), A computational approach to characterizing bond linkage of glycan isomers using MALDI-TOF-TOF mass spectrometry, Rapid Comm. Mass Spec. in press.
2. C. Shen, Q. Sheng, J. Dai, Y. Li, R. Zeng, H. Tang (2008), On the estimation of false positives in peptide identifications using decoy search strategy, Proteomics, in press.
3. C. Yuan, Q. Sheng, H. Tang, Y. Li, R. Zeng, R. J. Solaro (2008), Quantitative comparison of Sarcomeric phosphoproteomes of neonatal and adult rat hearts, Am. J Physiol. Heart Circ. Physiol., in press.
4. Y. Ye, H. Tang (2008), An ORFome assembly approach to metagenomics sequences analysis. Proceedings of the 7th Annual International Conference on Computational Systems Biology (CSB'08), 3-13. CSB online
5. Y. F. Li, R. J. Arnold, Y. Li, P. Radivojac, Q. Sheng, H. Tang (2008), A Bayesian approach to protein inference problem in shotgun proteomics. Proceedings of the 12th Annual International Conference on Computational Molecular Biology (RECOMB08), LNBI 4955, 167-180. LNBI online
6. S. Saha, S. H. Harrison, C. Shen, H. Tang, P. Radivojac, R. J. Arnold, X. Zhang, J. Y. Chen (2008), HIP2: An online database of human plasma proteins from healthy individuals. BMC Med Genomics. 1:12. Pubmed
7. J. H. Choi, S. Kim, H. Tang, J. Andrew, D. G. Gilbert, J. K. Colbourne (2008), A machine-learning approach to combined evidence validation of genome assemblies, Bioinformatics, 24(6):744-50. Pubmed
8. P. Alves, R. J. Arnold, D. E. Clemmer, Y. Li, J. P. Reilly, Q. Sheng, H. Tang, Z. Xun, R. Zeng, and P. Radivojac (2008), Fast and accurate identification of semi-tryptic peptides in shotgun proteomics, Bioinformatics, 24: 102-109. Pubmed
9. Z. Jiang, H. Tang, M. Ventura, M. F. Cardone, T. Marques-Bonet, X. She, P. A. Pevzner, E. E. Eichler (2007), Ancestral reconstruction of segmental duplications reveals punctuated cores of human genome evolution. Nat Genet. 39:1361-1368. Pubmed, Commentary on Nature Genetics.
10. H. Tang (2007) Genome assembly, rearrangement and repeats, Chem Rev., 107(8):3391-3406. Pubmed.
11. S. H. Bae, H. Tang, J. Wu, J. Xie and S. Kim (2007), dPattern: transcription factor binding site (TFBS) discovery in human genome using a discriminative pattern analysis. 23:2619-2621. Pubmed.
12. M. Rho, J. H. Choi, S. Kim, M. Lynch and H. Tang (2007), De novo identification of LTR retrotransposons in eukaryotic genomes. BMC Genomics, 8:90. Pubmed.
13. A. Sundquist, M. Ronaghi, H. Tang, P. A. Pevzner and S. Batzoglou (2007), Whole-genome sequencing and assembly with high-throughput, short-read technologies. PLoS ONE, 2:e484. Pubmed.
14. Y. Wu, Y. Mechref, I. Klouckova, M. V. Novotny and H. Tang (2007), A computational approach for the identification of site-specific protein glycosylations through ion-trap mass spectrometry, The Third RECOMB Satellite meeting on Proteomics, Lecture Notes in Bioinformatics, 4532:96-107, LNCS online.
15. P. Alves, R. J. Arnold, M. V. Novotny, P. Radivojac, J. P. Reilly and H. Tang (2007), Advancement in protein inference from shotgun proteomics using peptide detectability. Pacific Symposium on Biocomputing, 12:409-420. Fulltext from PSB online proceeding.
16. R. Patwardhan, H. Tang, S. Kim and M. Dalkilic (2006), An approximate de Bruijn graph approach to multiple local alignment and motif discovery in protein sequences, The First International Workshop in data mining and bioinformatics, Lecture Notes in Bioinformatics, 4316:158-169.
17. D. Zhi, B. Raphael, A. Price, H. Tang and P. Pevzner (2006), Identifying repeat domains in large genomes, Genome Biology, 7(1):R7, Pubmed.
18. D. Zhi, R. Keich, P. Pevzner, S. Heber and H. Tang (2006), Checking for base-calling errors in repeats. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 4(1):54-64, 2007, Pubmed
19. H. Tang, R. J. Arnold, P. Alves, Z. Xun, D. E. Clemmer, M. V. Novotny, J. P. Reilly and P. Radivojac (2006), A computational approach toward label-free protein quantification using predicted peptide detectability. Bioinformatics, 22(14):e481-488, ISMB 2006. Pubmed.
20. V. Bafna, H. Tang and Shaojie Zhang (2006), Consensus Folding of Unaligned RNA Sequences Revisited. J. Comp. Biol. 13(2):283-295, Pubmed.
21. R. J. Arnold, N. Jayasankar, D. Aggarwal, H. Tang and P. Radivojac (2006), A machine learning approach to predicting peptide fragmentation spectra. Proceeding of Pacific Symposium on Biocomputing, 11:219-230, Fulltext from PSB online proceeding.
22. H. Tang, Y. Mechref and M. Novotny (2005), Automatic Interpretation of MS/MS Spectra of Oligosaccharides. Bioinformatics, 21 Suppl 1:i431-i439, ISMB 2005, Pubmed
23. V. Bafna, H. Tang and Shaojie Zhang (2005), Consensus Folding of Unaligned RNA Sequences Revisited. Proceedings of the Ninth Annual International Conference on Computational Molecular Biology (RECOMB'05), 172-187, May 2005, Boston, USA, ACM.
24. B. Raphael, D. Zhi, H. Tang and P. A. Pevzner, A novel method for multiple alignment of sequences with repeats and shuffled elements. Genome Res. 2004, 14: 2336-2346. Pubmed
25. N. Bandeira, H. Tang, V. Bafna and P. A. Pevzner, Shotgun protein sequencing by tandem mass assembly. Analytical Chemistry, 2004, 76:7221-33. Pubmed
26. P. A. Pevzner, H. Tang and G. P. Tesler, De novo repeat classification and fragment assembly. Genome Res. 2004 Sep; 14(9): 1786-96. Pubmed
27. M. Chaisson M, P. A. Pevzner and H. Tang, Fragment assembly with short reads. Bioinformatics. 2004 Sep 1; 20(13): 2067-74. Pubmed
28. P. A. Pevzner, H. Tang and G. P. Tesler, De novo repeat classification and fragment assembly. Proceedings of the Eighth Annual International Conference on Computational Molecular Biology (RECOMB'04), April 2004, San Diego, USA, ACM Press. 2004 Sep; 14(9): 1786-96.
29. S. Heber, M. Alekseyev M, S. H. Sze, H. Tang and P. A. Pevzner, Splicing graphs and EST assembly problem. Bioinformatics. 2002; 18 Suppl 1 :S181-8 (ISMB 2002 issue). Pubmed
30. P. A. Pevzner and H. Tang, Fragment assembly with double-barreled data. Bioinformatics. 2001 Jun;17 Suppl 1:S225-33 (Special ISMB 2001 issue). Pubmed
31. P. A. Pevzner, H. Tang and M. S. Waterman (2001) A New Approach to Fragment Assembly in DNA Sequencing. Proceedings of the Fifth Annual International Conference on Computational Molecular Biology (RECOMB'01), April 2001, Montreal, Canada, ACM Press.
32. Q. Tu, H. Tang and D. Ding, MedBlast: searching articles related to a biological sequence. Bioinformatics. 2004,20:75-77. Pubmed
33. P. A. Pevzner, H. Tang and M. S. Waterman (2001), An Eulerian path approach to DNA fragment assembly. Proc. Natl. Acad. Sci. USA, 98:9748-9753. Pubmed Nature News
34. S. Kruglyak and H. Tang (2001) A New Estimator of Significance of Correlation in Time Series Data, J. Comp. Biol. 2001,8:463-470. Pubmed
35. S. Kruglyak and H. Tang (2000) Regulation of Adjecent Yeast Genes. Trends in Genetics, 16:109-111. Pubmed