Lecture Material

Lecture

Date

Topic

Lecture material

Homework/

Exam

1

8/30

Introduction : Introduction to the class and to molecular biology: Overview

PDF

Quiz (no credit)

2

9/1

Bio molecules

PDF

 

3

9/6

 Cell Structure: membrane structure and membrane transport

PDF

 

4

9/8

Cell Structure: membrane transport and Intracellular compartment (nucleus and mitochondria)

PDF

5 9/13 Cell Structure: Intracellular compartment and protein sorting (ER and vesicular traffic) PDF

6

9/15

Proteins – Lysosomes and proteins

PDF

 

7

9/20

-  Protein structure

PDF

 

8

9/22

-  Protein folding

PDF

homework (Cell and protein)

9

9/27

- Protein folding, modification, and degradation

(visit Cell Culture Lab)

PDF

 

10

9/29

- functional designs of proteins

- introduction to genetics

PDF

Journal assignment

(fund. Mol)

11

10/4

Genetics:

- Chromosome, chromatin,    and DNA

- Chromosome theory

- Gene, genetics, genome

- Mendelian genetics

- Sex determination, sex linkage, recombination

 

PDF

 

12

10/6

- DNA replication, repair and recombination

PDF

 

13

10/11

- How cells read the genome: from DNA to Protein (genetic code, tRNAs, protein synthesis)

PDF

 Quiz

14

10/13

- Control of Gene expression in Prokaryotes and Eukaryotes

PDF

 

15

10/18

MIDTERM

 

1st. Assignment due

16

10/20

Molecular biology techniques

-  Model organisms

-  Genotype studies: RFLPs, VNTRs, microsatellites, SNP

 

PDF

 

17

10/25

-  cDNA and ESTs

PDF

 

18

10/27

-  Recombinant DNA I

PDF

 

19

11/1

-  Recombinant DNA  II

PDF

Quiz

20

11/3

-  Sequence alignment

PDF

Journal assignment

(mol tech.)

21

11/8

-  Multiple sequence alignment and BLAST

-  Annotating genomes

PDF

 

22

11/10

-  Microarrays: gene expression analysis

PDF

 

23

11/15

-  Proteomics: mass spectrometry and protein-protein interaction

PDF

 

24

11/17

Topics in molecular Biology

-  Frog development

 

PDF

Quiz (tech.)

25

11/22

-  Fly development

PDF

 

Thanksgiving

11/24

 

 

 

26

11/29

-       Immunity

PDF

2nd assignment due

27

12/1

-       Cancer and infectious diseases

PDF

 

28

12/6

-       Genomics for biodiversity

Guest speaker : John K. Colbourne

PDF

 

29

12/8

FINAL EXAM

 

 

 

Reading assignment:

1. Doolittle RF. 1995. Annu. Rev. Biochem . 64 :287-314. The Multiplicity of domains in proteins (PDF)

 

Movies and Animations

Molecular Biology of the Cell. (4th ed.)

 

L 504 mainpage / Sukamol S. Jakobsson